Elishalom Yechiel, Ph.D.

Post Doctoral Fellow, Johns Hopkins University, Department of Biology,Baltimore, MD, 1985-1987.
Sponsor: Dr. Michael Edidin.

Ph.D. Biochemistry, The Hebrew University, Hadassah Medical School, Jerusalem, Israel. 1984.
Thesis: Relationship Between Membrane Lipid Composition and Chemical, Physical, and Biological Properties of Cell Membranes.

M.Sc. Biochemistry, The Hebrew University, Hadassah Medical School, Jerusalem, Israel. 1979.

B. Sc. Biochemistry, University of Bar-Ilan, Tel Aviv, Israel. 1976.

• anti-aging: novel working models and applications
• anti-cancer targeting
• biophysical and biochemical aspects of lipids and membrane structures and functions
• topical formulations: emulsion and encapsulation, intra- and inter-dermal drug delivery vehicles
• theoretical and applied nano-technologies
• botanicals and their active constituents and methods of extraction
• novel concepts of dynamic synergy and latent synergy and their effects on drug design logic

1997-present	Founder, President, and Director of Research Elsom Research Co., Inc., San Antonio, TX
1993-1996	Assistant Professor Department of Medicine University of Texas Health Science Center, San Antonio, TX
1991-1992	Independent research on funding allocation and process management for drug-discovery start-up.
1988-1990	Visiting Associate Laboratory of Biological Chemistry, Gerontology Research Center, National Institute on Aging National Institutes of Health, Baltimore, MD
1987-1988	Visiting Associate Endocrinology Section, Gerontology Research Center, National Institute on Aging National Institutes of Health, Baltimore, MD

Selected Presentations

"Nanomaterial Versus Nanotechnologies: Scale-up Limitations and Challenges in Topical Formulations."
San Antonio Nanotechnology Forum . San Antonio, TX. November 16, 2016.

"Phospholipids and Polarity Modifiers in Shape-shifting Liposomes and Their Role as Templates for Nano-Construction."
American Association of Oil Chemists . San Antonio, TX. May 7, 2014.

"Nano-Encapsulation Technology Overcomes Aesthetic Limitations of Food and Skincare Ingredients."
nanoTX'08. Dallas, TX. October 3, 2008.

"Nano-Particles Versus Nano-Tooling."
Nanomaterials Application Center Nanotechnology Colloquium. San Antonio, TX. September 8, 2008.

"Too Much Anti-Oxidant?"
Accelerating the Future. New York, NY. March 18, 2008.

"Beyond Nano-Sizing: Integrated Physico-Chemical Nano-Engines in Cosmeceuticals."
HBA Product Development Master Class: New Developments in Nanotechology. New York, NY. September 13, 2006.

"A Novel Super Anti-Oxidant with Excellent Intra-Dermal Penetration for Topical Formulations."
Personal Care Ingredients Technology Expo: High Performance Ingredients. New York, NY. April 18, 2006.

"Anti-Aging Actives in Nano-Cosmeceuticals: The Theory of Bio-Structural Aging."
HBA Product Development Master Class: New Developments in Nanotechology. New York, NY. September 25, 2005.

"Overcoming Aesthetic Limitations in Formulating Natural Ingredients and Enhancing Their Performance with Encapsulation Technology."
Personal Care Ingredients Technology Expo: High Performance Ingredients. New York, NY. April 14, 2004.

"More Than The Sum of Ingredients: Interactive Vehicles in Advanced Cosmeceuticals."
Personal Care Ingredients Technology Expo: High Performance Ingredients. New York, NY. April 14, 2004.

Selected Publications and Patents

2004-present, Scientific Editor, The Journal of Topical Formulations (ISSN 1554-0197).
Feature articles contributed include:

• "Dynamic Synergy as an Approach to Combining Cosmeceuticals. " July 2008. Volume 2, Issue 1.
• "Detergents and Surfactants in Soaps, Shampoos, and Other Cleansers. " April 2005. Volume 1, Issue 4.
• "Anti-Oxidants, Oxidative Stress, and Cellular Aging. " March 2005. Volume 1, Issue 3.
• "Defining Natural Ingredients by Source and Method of Extraction. " February 2005. Volume 1, Issue 2.
• "Cosmeceuticals, Liposomes, and Phosphatidylcholine. " January 2005. Volume 1, Issue 1.

Yechiel, E. 2005. "Interactive Vehicles in Synergistic Cosmeceuticals: Advances in Nano-Encapsulation, Transportation, Transfer, and Targeting." Delivery System Handbook for Personal Care and Cosmetic Products: Technology, Applications and Formulations. William Andrew Publishing. Ed. M. R. Rosen.

Yechiel, E. and R. Coste. 2005. "From Ancient Potions To Modern Lotions: A Technology Overview and Introduction to Topical Delivery Systems." Delivery System Handbook for Personal Care and Cosmetic Products: Technology, Applications and Formulations. William Andrew Publishing. Ed. M. R. Rosen.

2002, "Method of Reducing Age-Related Changes in Heart Muscle Cells", for treatment of age-related disorders. U.S.A. Patent No. 6,348,213.

Yechiel, E. and M. Edidin. 1994. "The Domain Structure of Membranes." Mobility and Proximity in Biological Membranes. CRC Press, ISBN 0-8493-4931-1, pp126-127. Ed. M. Edidin et al.

1990, "Improvements in Heart and Respiratory Function", following intravenous injection of small unilamellar liposomes. European Patent No. EP 0 234 919 B1.

1989, "Lipid Replacement Therapy", for treatment of age-related disorders. U.S.A. Patent No. 4,812,314.

Yechiel, E., and M. Edidin. 1987. "Micron scale domains in fibroblast plasma membranes.". J. Cell. Biol. 705: 755-760.

Moscona-Amir, E., Y.I. Henis, E. Yechiel, Y. Barenholz, and M. Sokolovsky. 1986. "Role of lipids in age related changes in the properties of muscarinic receptors in cultured rat heart myocytes."Biochemistry. 25:8118-8124.

Yechiel, E., and Y. Barenholz. 1986. "Cultured heart cell reaggregates: A model for studying relationship between aging and lipid composition."Biochem. et Biophys. Acta. 859:105-109.

Yechiel, E., Y.I. Henis, and Y. Barenholz. 1986. "Aging of rat heart fibroblasts; Relationship between lipid composition, membrane organization, and biological properties." Biochem. Et Biophys. Acta. 859:95-104.

Yechiel, E. and Y. Barenholz, and Y.I. Henis. 1985. "Lateral mobility and organization of phospholipids and protein in rat myocyte membranes." J. Biol. Chem. 260:9132-9136.

Yechiel, E., and Y. Barenholz. 1985. "Relationships between membrane lipid composition and biological properties of rat myocytes." J. Biol. Chem. 260:9123-9131.

Bkaily, G., N. Sperelakis, E. Yechiel and Y. Barenholz. 1983. "Effect of Na+ or Ca²+ filled liposomes on electrical activity of cultured heart cells." Am. J. Physiol. 245: H756-H761.

Barenholz, Y., and E. Yechiel, R. Cohen, and R.J. Deckelbaum. 1981. "Importance of cholesterol phospholipid interaction in determining dynamics of normal and abetalipoproteinemia red blood cell membranes." Cell Biophysics. 3:115-126.

Honors, Grants, Unique Achievements

1980, "Best Lecturer of The Year" in Biochemistry, Hadassah Medical School, Jerusalem

1981, "Best Lecturer of The Year" in Biochemistry, Hadassah Medical School, Jerusalem

1982, "Best Lecturer of The Year" in Biochemistry, Hadassah Medical School, Jerusalem

1983, "Best Lecturer of The Year" in Biochemistry, Hadassah Medical School, Jerusalem

1984, The Annual Prize for the Best Ph.D. Thesis. Awarded by the Faculty of Medicine, Hebrew University, Hadassah Medical School.

2008, Judge, Nano Night '08 Nanoscience and Nanotechnology Poster Session, Department of Nanotechnology, The University of Texas at Austin.

Examined and evaluated projects for the Nano Night contest, at which more than sixty graduate students and post-doctoral researchers competed for best project awards in several nanotechnology-related disciplines.

Geriatric Leadership Academic Award - Grant No. NIK K07 AG00469 from National Institute on Aging.

Institutional Research Grant Award - T-RAHW-OO-208-O.

Human trials of my therapeutic inventions for treatment of respiratory disorders and high cholesterol were conducted at Hadassah Medical Center in Jerusalem, Israel. The treatment is currently marketed by Infuturia Global and is available at clinics in Switzerland and in England.

"Squidoline", a novel compound I invented, has proved to be 10-100 times more effective than liposomes as a delivery vehicle for anti-cancer drugs, killing one hundred per cent of breast cancer cells in culture. Squidoline is in patent processing.

Developed innovative nano-biotechnologies including Nanosomes™, nano-emulsions, nano-encapsulations, and double nano-emulsions.

Created more than three hundred formulations for topical application to skin as cosmetics, cosmeceuticals, and pharmaceuticals and invented The-Formulator.com, a system by which custom micro-batches are produced in response to individual consumers' ingredient selections.